Lechward K, Awotunde O S, Swiatek W, Muszyńska G
Cell and Molecular Signaling Laboratory, Intercollegiate Faculty of Biotechnology Medical University of Gdańsk, Poland.
Acta Biochim Pol. 2001;48(4):921-33.
Protein phosphatase 2A (PP2A) comprises a diverse family of phosphoserine- and phosphothreonine-specific phosphatases present in all eukaryotic cells. All forms of PP2A contain a catalytic subunit (PP2Ac) which forms a stable complex with the structural subunit PR65/A. The heterodimer PP2Ac-PR65/A associates with regulatory proteins, termed variable subunits, in order to form trimeric holoenzymes attributed with distinct substrate specificity and targeted to different subcellular compartments. PP2Ac activity can be modulated by reversible phosphorylation on Tyr307 and methylation on C-terminal Leu309. Studies on PP2A have shown that this enzyme may be implicated in the regulation of metabolism, transcription, RNA splicing, translation, differentiation, cell cycle, oncogenic transformation and signal transduction.
蛋白磷酸酶2A（PP2A）是一个多样化的磷酸丝氨酸和磷酸苏氨酸特异性磷酸酶家族，存在于所有真核细胞中。所有形式的PP2A都包含一个催化亚基（PP2Ac），它与结构亚基PR65/A形成稳定的复合物。异二聚体PP2Ac-PR65/A与称为可变亚基的调节蛋白结合，以形成具有不同底物特异性并靶向不同亚细胞区室的三聚体全酶。PP2Ac的活性可以通过Tyr307上的可逆磷酸化和C末端Leu309上的甲基化来调节。对PP2A的研究表明，这种酶可能参与代谢、转录、RNA剪接、翻译、分化、细胞周期、致癌转化和信号转导的调节。
