Elvira C, Mano J F, San Román J, Reis R L
Department of Polymer Engineering, University of Minho, Braga, Portugal.
Biomaterials. 2002 May;23(9):1955-66. doi: 10.1016/s0142-9612(01)00322-2.
The design and preparation of novel biodegradable hydrogels developed by the free radical polymerization of acrylamide and acrylic acid, and some formulations with bis-acrylamide, in the presence of a corn starch/ethylene-co-vinyl alcohol copolymer blend (SEVA-C), is reported. The redox system benzoyl peroxide (BPO) and 4-dimethylaminobenzyl alcohol (DMOH) initiated the polymerization at room temperature. Xerogels were characterized by 1H NMR and FTIR spectroscopies. Swelling studies were performed as a function of pH in different buffer solutions determining the water-transport mechanism that governs the swelling behaviour. Degradation studies of the hydrogels were performed in simulated physiological solutions for time up to 90 days, determining the respective weight loss, and analyzing the solution residue by 1H NMR. The mechanical properties of the xerogels were characterized by tensile and compressive tests, as well as by dynamo-mechanical analysis (DMA). Dynamo-mechanical parameters are also reported for hydrated samples.
报道了由丙烯酰胺和丙烯酸在玉米淀粉/乙烯-共-乙烯醇共聚物共混物（SEVA-C）存在下通过自由基聚合制备的新型可生物降解水凝胶及其与双丙烯酰胺的一些配方。氧化还原体系过氧化苯甲酰（BPO）和4-二甲基氨基苄醇（DMOH）在室温下引发聚合反应。通过1H NMR和FTIR光谱对干凝胶进行表征。在不同缓冲溶液中，作为pH的函数进行溶胀研究，确定控制溶胀行为的水传输机制。在模拟生理溶液中对水凝胶进行长达90天的降解研究，确定各自的重量损失，并通过1H NMR分析溶液残留物。通过拉伸和压缩试验以及动态力学分析（DMA）对干凝胶的力学性能进行表征。还报道了水合样品的动态力学参数。
