人唾液黏蛋白的结构与生物合成
Structure and biosynthesis of human salivary mucins.
作者信息
Zalewska A, Zwierz K, Zółkowski K, Gindzieński A
机构信息
Department of Pharmaceutical Biochemistry Institute of Chemistry, Białystok, Poland.
出版信息
Acta Biochim Pol. 2000;47(4):1067-79.
Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.
人类唾液腺分泌两种类型的黏蛋白
分子量超过1 MDa的寡聚黏蛋白（MG1）和分子量为200 - 250 kDa的单体黏蛋白（MG2）。MG1和MG2的单体含有位于分子中央结构域的高度O - 糖基化串联重复序列。MG1单体通过位于糖基化程度较低的N端和C端的二硫键相连。MG1由人类唾液腺的黏液细胞合成，MG2由浆液细胞合成。
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