Burgaz Sema, Demircigil Gonca Cakmak, Karahalil Bensu, Karakaya Ali Esat
Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
Chemosphere. 2002 Apr;47(1):57-64. doi: 10.1016/s0045-6535(01)00185-0.
Urban air contains a diversity of chemical compounds, some of which are genotoxins. An increased risk of cancer has also been reported in occupations with heavy exposure to traffic-related pollution. The aim of this study was to assess the cytogenetic effects of urban air pollution by analyzing the chromosomal aberration (CA) frequencies in lymphocytes and to estimate the polycyclic aromatic hydrocarbons (PAHs) exposure by measuring urinary 1-hydroxypyrene (1-OHP) levels. A total of 15 traffic policemen and 17 taxi drivers working in the city of Ankara were the exposed groups and 23 healthy men working in the office departments were the control group. The overall mean +/- S.D. values of 1-OHP excretions of traffic policemen, taxi drivers and control subjects were 0.59 +/- 0.40 micromol/mol creatinine, 0.32 +/- 0.25 micromol/mol creatinine and 0.57 +/- 0.36 micromol/mol creatinine, respectively. Urinary 1-OHP levels of non-smoking policemen were significantly greater than those of nonsmoking control subjects (p < 0.05). The overall mean +/- S.D. values for CA frequencies (%) from policemen, taxi drivers and control group were 1.29 +/- 1.59, 1.81 +/- 1.79, and 0.26 +/- 0.73, respectively. There was a significantly greater frequency of CAs in exposed groups relative to the matched control population (p < 0.05; p < 0.01). Age, sex and smoking habits have not influenced the cytogenetic end-point in this study. Our results demonstrate that occupational exposure to urban air pollutants leads to a significant induction of cytogenetic damage in peripheral lymphocytes of traffic policemen and taxi drivers.
城市空气中含有多种化合物，其中一些是基因毒素。据报道，在大量接触交通相关污染的职业中，患癌风险也会增加。本研究的目的是通过分析淋巴细胞中的染色体畸变（CA）频率来评估城市空气污染的细胞遗传学效应，并通过测量尿中1-羟基芘（1-OHP）水平来估计多环芳烃（PAH）的暴露情况。共有15名在安卡拉市工作的交通警察和17名出租车司机作为暴露组，23名在办公室部门工作的健康男性作为对照组。交通警察、出租车司机和对照组的1-OHP排泄总体平均±标准差分别为0.59±0.40微摩尔/摩尔肌酐、0.32±0.25微摩尔/摩尔肌酐和0.57±0.36微摩尔/摩尔肌酐。不吸烟警察的尿中1-OHP水平显著高于不吸烟对照组（p<0.05）。警察、出租车司机和对照组的CA频率（%）总体平均±标准差分别为1.29±1.59、1.81±1.79和0.26±0.73。与匹配的对照人群相比，暴露组的CA频率显著更高（p<0.05；p<0.01）。在本研究中，年龄、性别和吸烟习惯并未影响细胞遗传学终点。我们的结果表明，职业性接触城市空气污染物会导致交通警察和出租车司机外周淋巴细胞中细胞遗传学损伤的显著诱导。
