Nowak G, Koth W
Acta Biol Med Ger. 1975;34(6):1037-41.
A technique for measuring the oxygen consumption of small laboratory animals suitable for pharmacological and toxicological studies is described. The oxygen consumption of the animal in the respiratory chamber is compensated by means of a photoelectrically operating servo mechanism from an oxygen reservoir. The oxygen supplied is directly recorded via a transducer by an X-Y recorder. The carbon dioxide exhaled by the animal is entirely absorbed. Composition and pressure of air in the respiratory chamber correspond to the physiological medium. The usefulness of this technique is demonstrated by investigations on the effects of epinephrine and morphine on the oxygen consumption of rats.
本文描述了一种适用于药理学和毒理学研究的测量小型实验动物耗氧量的技术。呼吸室内动物的耗氧量通过一个由氧气储存器驱动的光电伺服机构来补偿。供应的氧气通过一个传感器由一台X-Y记录仪直接记录。动物呼出的二氧化碳被完全吸收。呼吸室内空气的成分和压力与生理介质一致。通过对肾上腺素和吗啡对大鼠耗氧量影响的研究证明了该技术的实用性。
