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地塞米松对X线照射家兔急性高血压所致血脑屏障损伤的影响

Dexamethasone effect on blood-brain barrier damage caused by acute hypertension in x-irradiated rabbits.

作者信息

Blomstrand C, Johansson B, Rosengren B

出版信息

Acta Neurol Scand. 1975 Oct;52(4):331-4. doi: 10.1111/j.1600-0404.1975.tb05828.x.

DOI:10.1111/j.1600-0404.1975.tb05828.x
PMID:1199696
Abstract

Unilateral X-ray exposure of brain increases the vulnerability of cerebral vessels to acute hypertension in the brain hemisphere exposed to radiation. A preventive effect of dexamethasone was observed when treatment with the drug was started before irradiation; but also when the drug was given 24 h before acute hypertension was induced, 1 week after irradiation.

摘要

单侧脑部X线照射会增加受辐射脑半球脑血管对急性高血压的易感性。当在照射前开始使用地塞米松治疗时,观察到该药物具有预防作用;而且在照射1周后,在诱发急性高血压前24小时给予该药物时也观察到了预防作用。

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