迟发性重带电粒子辐射损伤中的脑血管和代谢紊乱

Cerebrovascular and metabolic perturbations in delayed heavy charged particle radiation injury.

作者信息

Lo E H, Frankel K A, Delapaz R L, Poljak A, Woodruff K H, Brennan K M, Phillips M H, Valk P E, Steinberg G K, Fabrikant J I

机构信息

Department of Biophysics and Medical Physics, University of California, Berkeley 94720.

出版信息

Brain Res. 1989 Dec 11;504(1):168-72. doi: 10.1016/0006-8993(89)91619-3.

DOI:10.1016/0006-8993(89)91619-3

PMID:2598014

Abstract

Focal heavy charged particle irradiation of the rabbit brain created defined lesions which were observable by nuclear magnetic resonance (NMR) and positron emission tomography (PET) imaging techniques. The lesions appeared approximately 9-11 months after left partial hemibrain irradiation with 30 Gy (230 MeV/u helium ions), and were restricted to the white matter tracts and deep perithalamic and thalamic regions. 82Rubidium PET and Gadolinium DTPA enhanced NMR imaging were used to detect blood-brain barrier perturbations. 18Fluordeoxyglucose PET studies demonstrated widespread decreases in cerebral glucose uptake in the cortex and thalamus of the irradiated hemisphere. NMR and PET imaging results correlated well with histological findings. Rabbits irradiated with 15 Gy did not demonstrate any abnormalities in the brain with sequential NMR scans through 14 months post-irradiation.

摘要

对兔脑进行局部重带电粒子照射会产生特定的损伤，这些损伤可通过核磁共振（NMR）和正电子发射断层扫描（PET）成像技术观察到。在用30 Gy（230 MeV/u氦离子）对左半脑部分进行照射后约9 - 11个月出现损伤，且损伤局限于白质束以及丘脑周围深部和丘脑区域。使用82铷PET和钆喷酸葡胺增强NMR成像来检测血脑屏障的扰动。18氟脱氧葡萄糖PET研究表明，受照射半球的皮质和丘脑中脑葡萄糖摄取普遍减少。NMR和PET成像结果与组织学发现密切相关。接受15 Gy照射的兔子在照射后14个月内进行的连续NMR扫描中未显示出大脑有任何异常。