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Further evidence implicating E-type prostaglandins in the patency of the lamb ductus arteriosus.

作者信息

Olley P M, Bodach E, Heaton J, Coceani F

出版信息

Eur J Pharmacol. 1975 Nov;34(1):247-50. doi: 10.1016/0014-2999(75)90248-4.

Abstract

A blocker of prostaglandin (PG) snythesis, indomethacin, given to pregnant ewes near term produces constriction of the lamb ductus arteriosus in utero. The result supports the hypothesis formulated previously that E-type prostaglandins, which are potent relaxant on the ductus, are responsible for maintaining the patency of the vessel during foetal life.

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