Olley P M, Bodach E, Heaton J, Coceani F
Eur J Pharmacol. 1975 Nov;34(1):247-50. doi: 10.1016/0014-2999(75)90248-4.
A blocker of prostaglandin (PG) snythesis, indomethacin, given to pregnant ewes near term produces constriction of the lamb ductus arteriosus in utero. The result supports the hypothesis formulated previously that E-type prostaglandins, which are potent relaxant on the ductus, are responsible for maintaining the patency of the vessel during foetal life.