前列腺素E2（PGE2）对羔羊动脉导管的血管舒张作用比前列环素（PGI2）或6-酮-前列腺素F1α（6 keto PGF1α）更强。

PGE2 is a more potent vasodilator of the lamb ductus arteriosus than is either PGI2 or 6 keto PGF1alpha.

作者信息

Clyman R I, Mauray F, Roman C, Rudolph A M

出版信息

Prostaglandins. 1978 Aug;16(2):259-64. doi: 10.1016/0090-6980(78)90028-x.

Abstract

It has been shown in vitro that the lamb ductus arteriosus forms prostaglandins PGE2, PGF2alpha, 6 keto PGF1alpha (and its unstable precursor PGI2). In this study the relative potencies of these endogenous prostaglandins were investigated on isolated lamb ductus arteriosus preparations contracted by exposure to elevated PO2 and indomethacin. All the prostaglandins (except PGF2alpha) relaxed the vessel. This is consistent with the hypothesis that endogenous prostaglandins inhibit the tendency of the vessel to contract in response to oxygen. Only PGE2, however, relaxed the vessel at concentrations below 10(-8)M. PGI2 and 6 keto PGF1alpha had approximately 0.001 and 0.0001 times the activity of PGE2. Although PGE2 has been observed to be a minor product of prostaglandin production in the lamb ductus arteriosus, the tissue's marked sensitivity to PGE2 might make it the most significant prostaglandin in regulating the patency of the vessel.

摘要

体外实验表明，羊动脉导管可生成前列腺素PGE2、PGF2α、6-酮-PGF1α（及其不稳定前体PGI2）。在本研究中，对这些内源性前列腺素在因暴露于高氧分压和吲哚美辛而收缩的离体羊动脉导管标本上的相对效能进行了研究。所有前列腺素（PGF2α除外）均可使血管舒张。这与内源性前列腺素抑制血管因氧而收缩的倾向这一假说相符。然而，只有PGE2在浓度低于10^(-8)M时可使血管舒张。PGI2和6-酮-PGF1α的活性分别约为PGE2的0.001倍和0.0001倍。尽管PGE2在羊动脉导管中前列腺素生成中是次要产物，但该组织对PGE2的显著敏感性可能使其成为调节血管通畅性的最重要前列腺素。