Joki-Erkkilä Veli-Pekka, Aittoniemi Janne, Vuento Risto, Puhakka Heikki
Department of Otolaryngology, Tampere University Hospital, PO Box 2000, FIN-33521, Tampere, Finland.
Int J Pediatr Otorhinolaryngol. 2002 May 15;63(3):219-22. doi: 10.1016/s0165-5876(02)00012-5.
We studied the effect of concomitant nasopharyngeal carriage of beta-lactamase producing Moraxella catarrhalis and Haemophilus influenzae on the occurrence of penicillin resistance of Streptococcus pneumoniae. We took nasopharyngeal samples from 306 children with recurrent otitis media and a history of several antibiotic treatments. We could isolate at least one of the pathogens in 89 subjects. Of these children 13% carried more than one pathogen. Of the isolated M. catarrhalis and H. influenzae strains 93% and 43% produced beta-lactamase, respectively. Of the S. pneumoniae strains 25% were non-susceptible (I/R) to penicillin. However, in patients carrying beta-lactamase-producing M. catarrhalis together with pneumococci all strains were susceptible to penicillin (P=0.0353). This finding suggests that beta-lactamase producing M. catarrhalis may hinder the emergence of penicillin resistance of S. pneumoniae in children with recurrent acute otitis media.
我们研究了产β-内酰胺酶的卡他莫拉菌和流感嗜血杆菌同时存在于鼻咽部对肺炎链球菌青霉素耐药性发生的影响。我们从306名患有复发性中耳炎且有多次抗生素治疗史的儿童中采集了鼻咽样本。我们在89名受试者中分离出至少一种病原体。在这些儿童中，13%携带不止一种病原体。在分离出的卡他莫拉菌和流感嗜血杆菌菌株中，分别有93%和43%产生β-内酰胺酶。在肺炎链球菌菌株中，25%对青霉素不敏感（中介/耐药）。然而，在携带产β-内酰胺酶的卡他莫拉菌和肺炎球菌的患者中，所有菌株对青霉素均敏感（P=0.0353）。这一发现表明，产β-内酰胺酶的卡他莫拉菌可能会阻碍复发性急性中耳炎儿童中肺炎链球菌青霉素耐药性的出现。
