Guo Sydney S, Arora Charanjit, Shimoide Alan T, Sawicki Mark P
Department of Surgery, West Los Angeles VA Medical Center and the UCLA School of Medicine, 90095, USA.
Mol Cell Endocrinol. 2002 Apr 25;190(1-2):109-14. doi: 10.1016/s0303-7207(02)00002-3.
Pancreatic endocrine tumors (PETs) arise from neuroendocrine cells in and around the pancreas. As loss of heterozygosity (LOH) of chromosome 3 has been reported in sporadic PETs, we examined 16 sporadic PETs for LOH of 10 polymorphic DNA markers spanning both arms of chromosome 3. LOH was demonstrated in 4 of 8 (50%) sporadic PETs with hepatic metastasis, but in none of 8 sporadic PETs without hepatic involvement. The smallest common-deleted region (SCDR) mapped to 3q27-qter. Analysis of this data with the status of markers on chromosomes 1, 11, and MEN1 mutations in these 16 sporadic PETs revealed that chromosome 3q loss may be a late event in sporadic PET tumorigenesis. These data, combined with reports from other investigators, indicate that chromosome 3q27-qter may contain a tumor suppressor gene that's important in the tumorigenesis of sporadic PETs.
胰腺内分泌肿瘤（PETs）起源于胰腺内及其周围的神经内分泌细胞。由于在散发性PETs中已报道有3号染色体杂合性缺失（LOH），我们检测了16例散发性PETs中跨越3号染色体双臂的10个多态性DNA标记的LOH情况。在8例（50%）有肝转移的散发性PETs中有4例显示出LOH，但在8例无肝受累的散发性PETs中均未发现。最小共同缺失区域（SCDR）定位于3q27 - qter。对这16例散发性PETs中1号、11号染色体上标记物的状态以及MEN1突变情况进行数据分析后发现，3号染色体q臂缺失可能是散发性PET肿瘤发生过程中的一个晚期事件。这些数据，结合其他研究者的报告，表明3q27 - qter可能包含一个在散发性PETs肿瘤发生中起重要作用的肿瘤抑制基因。
