Remijnse P L, Eeckhout A M, van Guldener C
Afd. Algemene Inwendige Geneeskunde, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam.
Ned Tijdschr Geneeskd. 2002 Apr 20;146(16):768-71.
A 39-year-old man was admitted with myasthenia, alcoholic hepatitis and electrolyte abnormalities due to an inadequate nutritional state. On admission the ECG showed a prolonged QTc interval (0.46 s). The patient was treated with intravenous fluid and supplementary vitamins and minerals. On the third day of admission the patient developed a delirium, partly due to alcohol withdrawal, and was therefore treated with oxazepam 50 mg 3 times daily and a single dose of haloperidol 5 mg. One hour after ingesting haloperidol, the patient suddenly succumbed and resuscitation was not successful. The autopsy revealed a cardiomyopathy but no explanation for the sudden death. Due to the temporal relationship between the ingestion of haloperidol and this sudden death, we assume that haloperidol induced a fatal arrhythmia in the presence of a preexisting prolonged repolarisation time. To the best of our knowledge, sudden death after a single oral therapeutic dose of haloperidol has not previously been described.
一名39岁男性因营养状况不佳入院，患有重症肌无力、酒精性肝炎和电解质异常。入院时心电图显示QTc间期延长（0.46秒）。患者接受了静脉输液及补充维生素和矿物质治疗。入院第三天，患者出现谵妄，部分原因是酒精戒断，因此接受了每日3次、每次50毫克奥沙西泮及单次5毫克氟哌啶醇治疗。服用氟哌啶醇1小时后，患者突然死亡，复苏未成功。尸检发现有心肌病，但未找到猝死原因。鉴于服用氟哌啶醇与此次猝死之间的时间关系，我们推测氟哌啶醇在已有复极时间延长的情况下诱发了致命性心律失常。据我们所知，此前尚未有单次口服治疗剂量氟哌啶醇后猝死的报道。
