Shahabuddin Mohammed
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Trends Parasitol. 2002 Apr;18(4):157-61. doi: 10.1016/s1471-4922(01)02219-x.
Recent debate in Plasmodium ookinete invasion has been centered on whether the parasite chooses a specific cell type to cross the midgut epithelium in the mosquito. A few publications have described the mosquito midgut being composed of complex surface-structures, histochemically and biochemically diverse cell types, and have proposed that Plasmodium gallinaceum ookinetes prefers a specific cell type (Ross cell) in Aedes aegypti for crossing the midgut epithelium. Two recent publications reported, however, that with differential interference contrast microscopy, all midgut epithelial cells in uninfected mosquitoes appear structurally similar and argued that ookinetes do not invade a specific cell type. These observations are discussed here in the context of the 'Ross cell' hypothesis.
近期关于疟原虫卵囊入侵的争论集中在寄生虫是否选择特定细胞类型穿过蚊子中肠上皮。一些出版物描述了蚊子中肠由复杂的表面结构、组织化学和生物化学上不同的细胞类型组成，并提出鸡疟原虫卵囊在埃及伊蚊中更喜欢特定细胞类型（罗斯细胞）来穿过中肠上皮。然而，最近的两篇出版物报道，使用微分干涉相差显微镜观察，未感染蚊子的所有中肠上皮细胞在结构上看起来相似，并认为卵囊不会侵入特定细胞类型。在此将在“罗斯细胞”假说的背景下讨论这些观察结果。
