Casterline C L
Am Fam Physician. 1975 Nov;12(5):119-22.
The aspirin intolerance syndrome is characterized by rhinitis and/or sinusitis, nasal polyposis and asthma, with or without a history of adverse reactions, following aspirin ingestion. The frequency of this syndrome in a total population of patients with asthma and/or rhinitis has recently been estimated to be 2.4 percent. Aspirin-intolerant individuals can tolerate sodium salicylate and acetaminophen but indomethacin, morphine, codeine and certain pharmaceutical dyes may cause adverse reactions. The mechanism of aspirin intolerance is as yet unclear but does not appear to be on an immunologic basis. Treatment includes strict avoidance of aspirin and symptomatic therapy of rhinitis and asthma.
阿司匹林不耐受综合征的特征是在摄入阿司匹林后出现鼻炎和/或鼻窦炎、鼻息肉和哮喘，无论有无不良反应史。最近估计，在哮喘和/或鼻炎患者的总人口中，这种综合征的发生率为2.4%。阿司匹林不耐受个体可耐受水杨酸钠和对乙酰氨基酚，但吲哚美辛、吗啡、可待因和某些药物染料可能会引起不良反应。阿司匹林不耐受的机制尚不清楚，但似乎不是基于免疫。治疗包括严格避免使用阿司匹林以及对鼻炎和哮喘进行对症治疗。
