Ogino S, Harada T, Okawachi I, Irifune M, Matsunaga T, Nagano T
Acta Otolaryngol Suppl. 1986;430:21-7.
Asthma, aspirin intolerance and nasal polyps form a triad of aspirin-induced asthma (AIA). Eighteen cases, 6 males and 12 females, who complained of asthma attacks and/or rhinorrhea after ingestion of non-steroidal anti-inflammatory drugs were encountered over several years. The mean age of onset was 32.1 for asthma and 25.4 for rhinitis. Asthma was found in all of the 18 cases and nasal polyps in 13 cases (72.2%). The polyps were recurrent and 7 patients had undergone polypectomies. Urticaria was seen in 44.4% and sinusitis diagnosed by X-ray in 81.8%. Sensitivity to at least one allergen was found in 7 out of 9 cases (77.8%) and 6 out of 11 cases (54.5%) gave results positive for RAST. Eosinophilia was seen in 14 out of 16 patients (87.5%). The pathogenesis of AIA is obscure but is probably related to inhibition of prostaglandin biosynthesis. We concluded that AIA is not a rare disease in Japan either, and the studies for eosinophilia may be useful for elucidation of the pathogenesis of AIA and nasal polyps.
哮喘、阿司匹林不耐受和鼻息肉构成阿司匹林诱发哮喘（AIA）三联征。数年间共遇到18例患者，其中男性6例，女性12例，他们在摄入非甾体类抗炎药后出现哮喘发作和/或鼻漏。哮喘的平均发病年龄为32.1岁，鼻炎为25.4岁。18例患者均有哮喘，13例（72.2%）有鼻息肉。息肉呈复发性，7例患者接受过息肉切除术。44.4%的患者出现荨麻疹，81.8%的患者经X线诊断为鼻窦炎。9例中有7例（77.8%）对至少一种变应原敏感，11例中有6例（54.5%）RAST结果呈阳性。16例患者中有14例（87.5%）出现嗜酸性粒细胞增多。AIA的发病机制尚不清楚，但可能与前列腺素生物合成受抑制有关。我们得出结论，AIA在日本也并非罕见疾病，对嗜酸性粒细胞增多的研究可能有助于阐明AIA和鼻息肉的发病机制。
