Itoh Mitsuru, Yago Kazuhiro, Shimada Hideto, Tohyama Kaoru
Department of Internal Medicine, Shizuoka General Hospital, Shizuoka, Japan.
Int J Hematol. 2002 Apr;75(3):302-4. doi: 10.1007/BF02982046.
A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase increased. After discontinuation of CsA treatment, all of these levels rapidly decreased. We consider that CsA might accelerate disease progression in certain MDS cases.
一名38岁患有骨髓增生异常综合征（MDS）的日本男性，其骨髓涂片显示细胞增多，接受了口服环孢素A（CsA）治疗。在该治疗过程中，外周血和骨髓原始细胞数量增加，血清乳酸脱氢酶水平升高。停用CsA治疗后，所有这些水平迅速下降。我们认为CsA可能会加速某些MDS病例的疾病进展。
