Yang Xiao-Ping, Chiba Shigetoshi
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Tohoku J Exp Med. 2002 Mar;196(3):151-5. doi: 10.1620/tjem.196.151.
The periarterial nerve electrical stimulation at 4 and 10 Hz induced a monophasic vasoconstriction of the canine splenic artery in a pulse number-related manner (1-30 pulses). The responses at 4 Hz were not significantly affected by 0.1 microM prazosin, but abolished by 1 microM alpha, beta-methylene ATP. Prazosin (0.1 microM) partially but significantly inhibited responses at 10 Hz, and the remaining responses were blocked by 1 microM alpha, beta-methylene ATP. It indicates that the monophasic vasoconstrictor response to short pulses of stimulation at a low frequency is mediated by P2X-receptors, whereas the response at a high frequency may be due to activation of not only P2X-receptors but also alpha1 adrenoceptors.
4赫兹和10赫兹的动脉周围神经电刺激以脉冲数相关的方式（1 - 30个脉冲）诱导犬脾动脉出现单相血管收缩。4赫兹时的反应不受0.1微摩尔哌唑嗪的显著影响，但被1微摩尔α,β-亚甲基ATP消除。哌唑嗪（0.1微摩尔）部分但显著抑制10赫兹时的反应，其余反应被1微摩尔α,β-亚甲基ATP阻断。这表明低频短脉冲刺激引起的单相血管收缩反应由P2X受体介导，而高频时的反应可能不仅归因于P2X受体的激活，还归因于α1肾上腺素能受体的激活。
