Woo Elaine J, Starks Courtney M, Carney John R, Arslanian Robert, Cadapan Lawrence, Zavala Stefan, Licari Peter
Kosan Biosciences, Inc, Hayward, CA 94545, USA.
J Antibiot (Tokyo). 2002 Feb;55(2):141-6. doi: 10.7164/antibiotics.55.141.
Streptomyces platensis (strain NRRL 18993), a producer of dorrigocins, was shown to produce migrastatin, a cyclic congener of dorrigocin A previously reported from a different organism. Additionally a new compound isomeric to migrastatin, isomigrastatin, was also isolated and its structure was determined to be a cyclic form of dorrigocin B. Both compounds were fully characterized from MS and NMR data. Product titers of both were improved by the addition of XAD-16 resin to the fermentation medium.
普拉特链霉菌（菌株NRRL 18993）是多里戈星的产生菌，已证明其能产生迁移他汀，一种先前从不同生物体中报道的多里戈星A的环状同系物。此外，还分离出了一种与迁移他汀同分异构的新化合物——异迁移他汀，其结构被确定为多里戈星B的环状形式。这两种化合物均通过质谱和核磁共振数据进行了全面表征。通过向发酵培养基中添加XAD - 16树脂提高了两者的产物效价。
