De Rossi A
Department of Oncology and Surgical Science, Section of Oncology, AIDS Reference Center, University of Padua, Italy.
J Biol Regul Homeost Agents. 2002 Jan-Mar;16(1):53-7.
In the absence of any antiretroviral therapy, about one-third of infants with perinatally acquired HIV infection develop AIDS within the first months of life, while the remainder show slower disease progression. As the rate of viral replication during the first 3 months of life is strictly correlated with and predictive of disease outcome, any treatment that keeps the virus at low levels during primary infection might substantially modify the natural history of infection. Emerging data show that some infants treated early with highly active antiretroviral therapy have persistenty undetectable levels of HIV, and lack an HIV-specific immune response, despite preservation of immune functions. These findings strongly suggest that early therapeutic intervention might lead to a long-term suppression of viral replication.
在未接受任何抗逆转录病毒治疗的情况下，约三分之一围产期感染艾滋病毒的婴儿在出生后的头几个月内会发展为艾滋病，而其余婴儿的疾病进展则较为缓慢。由于出生后头3个月内的病毒复制率与疾病结局密切相关且具有预测性，因此在初次感染期间能将病毒维持在低水平的任何治疗方法都可能显著改变感染的自然病程。新出现的数据表明，一些早期接受高效抗逆转录病毒治疗的婴儿体内艾滋病毒水平持续检测不到，尽管免疫功能得以保留，但缺乏艾滋病毒特异性免疫反应。这些发现有力地表明，早期治疗干预可能会导致病毒复制的长期抑制。
