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围产期感染的年轻成年人中HIV抗体反应较弱：围产期感染的成年人中HIV抗体反应较弱。

Weak HIV Antibody Responses in Perinatally Infected Young Adults: Weak HIV Antibody Responses in Perinatally Infected Adults.

作者信息

Kirkpatrick Allison R, Unsal Aylin B, Blankson Joel N, Moore Richard D, Quinn Thomas C, Hadigan Colleen, Laeyendecker Oliver

机构信息

From the *Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Baltimore, MD; and †Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

出版信息

Pediatr Infect Dis J. 2017 Nov;36(11):1064-1066. doi: 10.1097/INF.0000000000001649.

DOI:10.1097/INF.0000000000001649
PMID:28650937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5638694/
Abstract

We compared the antibody response to HIV using 2 serologic cross-sectional incidence assays in adults with perinatally acquired HIV, to elite controllers and individuals exposed to antiretroviral therapy who were all infected as adults. Low antibody responses were seen more frequently in adults with perinatally acquired HIV, both overall and when stratified by viral suppression status.

摘要

我们使用两种血清学横断面发病率检测方法，比较了围产期感染HIV的成人、精英控制者以及成年后感染且接受抗逆转录病毒治疗的个体对HIV的抗体反应。在围产期感染HIV的成人中，无论是总体还是按病毒抑制状态分层时，低抗体反应更为常见。