Chlebovská K, Chlebovskỳ O, Ahlers I, Ahlersová E, Bacenková D
Department of Zoology and Ecology, Faculty of Sciences, P.J. Safárik University, Moyzesova 11, 041 67 Kosice, Slovak Republic.
Arch Ital Biol. 2002 Apr;140(2):91-100.
The effect of K and Mg salts of aspartic acid (Cardilan) on the serum concentration of selected proteins and phagocytic activity in aging male Wistar rats was investigated. Cardilan was administered in tap water for 7 days a month for 3 months before the last observed interval (12, 18 and 24 month). In a part of animals, the aging process was accelerated by sublethally gamma-irradiation. The administration of Cardilan slowed down the changes in the concentration of prealbumin, albumin, haptoglobin, haemopexin, C3 complement in non-irradiated rats (DC). This effect was extended to the changes in transferrin level in irradiated rats (IDC). The phagocytic activity in both DC, IDC rats was lower compared with controls drinking water (DW, IDW), but not significantly. The effect of Cardilan administration appears to be the greatest in 24-month-old rats, when the treated animals survived better by 25% in IDC group and by 26% better in DC rats, compared with those of the same age controls. Potassium and magnesium salts of aspartates are suitable compounds for life prolongation in the experimental conditions.
研究了天冬氨酸的钾盐和镁盐（卡尔迪兰）对衰老雄性Wistar大鼠血清中特定蛋白质浓度及吞噬活性的影响。在最后观察期（12、18和24个月）前3个月，每月用含卡尔迪兰的自来水给药7天。部分动物通过亚致死剂量的γ射线照射加速衰老进程。在未照射的大鼠（DC）中，给予卡尔迪兰减缓了前白蛋白、白蛋白、触珠蛋白、血红素结合蛋白、C3补体浓度的变化。这种作用在照射大鼠（IDC）中扩展到转铁蛋白水平的变化。与饮用对照水的大鼠（DW、IDW）相比，DC和IDC大鼠的吞噬活性均较低，但差异不显著。在24月龄大鼠中，给予卡尔迪兰的效果似乎最为显著，与同年龄对照组相比，治疗组动物在IDC组的存活率提高了25%，在DC大鼠中提高了26%。在实验条件下，天冬氨酸的钾盐和镁盐是适合延长寿命的化合物。
