Hecht G, Héry M
Institut National de Recherche et de Sécurité, Vandoeuvre les Nancy, France.
Ann Occup Hyg. 2002 Jan;46(1):89-96. doi: 10.1093/annhyg/mef010.
Given the physical properties of peroxyacetic acid, which decomposes into acetic acid and hydrogen peroxide, the generation and analysis of controlled atmospheres used to test the irritant potency of this peracid in mice require specific developments. The sampling and analytical method was based on the simultaneous sampling on a titanyl sulphate-impregnated silica gel tube (allowing the determination of total peroxides, peroxyacetic acid and hydrogen peroxide) and in an impinger containing a methyl-p-tolyl sulphide solution (of which the analysis yields the concentration of total acids, peroxyacetic acid and acetic acid, and peroxyacetic alone). From these results the concentrations of the different products can be inferred without interference. A special device composed of inert materials was designed for the generation of the controlled atmosphere. Buffering the peroxyacetic solution at pH 7 with a phosphate buffer allowed the generation of peroxyacetic acid atmospheres with negligible concentrations of acetic acid and hydrogen peroxide.
由于过氧乙酸的物理性质，它会分解为乙酸和过氧化氢，因此用于测试这种过酸对小鼠刺激性强度的可控气氛的生成和分析需要特定的改进。采样和分析方法基于在硫酸氧钛浸渍的硅胶管上同时采样（用于测定总过氧化物、过氧乙酸和过氧化氢）以及在含有对甲苯硫醚溶液的冲击式吸收瓶中采样（对其分析可得出总酸、过氧乙酸和乙酸以及单独的过氧乙酸的浓度）。根据这些结果，可以在无干扰的情况下推断出不同产物的浓度。设计了一种由惰性材料组成的特殊装置用于生成可控气氛。用磷酸盐缓冲液将过氧乙酸溶液的pH值调节至7，可以生成乙酸和过氧化氢浓度可忽略不计的过氧乙酸气氛。
