Hackstein Nils, Langheinrich Alexander C, Rau Wigbert S
Department of Diagnostic Radiology, Justus-Liebig Universität Giessen, Germany.
Clin Physiol Funct Imaging. 2002 Mar;22(2):99-107. doi: 10.1046/j.1365-2281.2002.00394.x.
The pharmacokinetics of iopromide were analysed using a two-compartment model. The optimal point of time for blood withdrawal for calculation of a one-sample clearance was determined.
Plasma concentration of iodine was measured up to 8 h postinjection (p.i.) in 62 adult patients who received 120 ml iopromide for computed tomography (CT). A two exponential function was fitted by a weighted least error square method. As reference method, clearance was calculated from this function and the injected amount of iodine. Empirical parameters for calculation of one-sample clearance were determined. This one-sample clearance was compared with one-sample clearance calculated according to formulas developed for Tc99m-DTPA by Jacobsson as well as a two sample method.
Total distribution volume of iopromide was calculated as 0.242 Lkg(-1)+/- 5.9%. A high correlation of all one-sample method and the two-sample method with reference to clearance was found. Best estimation of iopromide plasma clearance was achieved by determining one-sample clearance 270 or 285 min p. i. with SD(y.x) of 5.8 ml min(-1).
After administration of 120 ml iopromide, one-sample plasma clearance can be calculated with low estimation error taking one blood sample at an appropriate time point. Late phase pharmacokinetics of iopromide found in the present study showed to be virtually identical to results published for iohexol and Tc99m-DTPA.
采用二室模型分析碘普罗胺的药代动力学。确定用于计算单样本清除率的采血最佳时间点。
对62例接受120 ml碘普罗胺进行计算机断层扫描（CT）的成年患者，在注射后（p.i.）长达8小时测量血浆碘浓度。用加权最小误差平方方法拟合双指数函数。作为参考方法，根据该函数和碘的注射量计算清除率。确定计算单样本清除率的经验参数。将该单样本清除率与根据雅各布松为Tc99m - DTPA制定的公式计算的单样本清除率以及双样本方法进行比较。
碘普罗胺的总分布容积计算为0.242 Lkg(-1)±5.9%。发现所有单样本方法和双样本方法在清除率方面具有高度相关性。通过在注射后270或285分钟测定单样本清除率，SD(y.x)为5.8 ml min(-1)，可实现对碘普罗胺血浆清除率的最佳估计。
给予120 ml碘普罗胺后，在适当时间点采集一份血样，可计算单样本血浆清除率，估计误差较低。本研究中发现的碘普罗胺晚期药代动力学与已发表的碘海醇和Tc99m - DTPA的结果几乎相同。
