Yazama Futoshi, Kadonosono Kazuaki, Itoh Norihiko, Ohno Shigeaki
Department of Anatomy, School of Medicine, Yokohama City University, Kanagawa, Japan.
J Electron Microsc (Tokyo). 2002;51(2):127-31. doi: 10.1093/jmicro/51.2.127.
To investigate the possible role of matrix metalloproteinase-7 in choroidal neovascularization associated with age-related macular degeneration, immunoelectron microscopy using ultrathin frozen sections and conventional transmission electron microscopy were performed in subfoveal fibrovascular membranes from patients with age-related macular degeneration. immunoelectron microscopy revealed that matrix metalloproteinase-7 was expressed within basal laminar deposits and amorphous materials around the retinal pigment epithelial cells. The results support a role for matrix metalloproteinase-7 in the development of choroidal neovascularization in age-related macular degeneration.
为研究基质金属蛋白酶-7在年龄相关性黄斑变性相关脉络膜新生血管形成中的可能作用，对年龄相关性黄斑变性患者的中心凹下纤维血管膜进行了超薄冰冻切片免疫电子显微镜检查和传统透射电子显微镜检查。免疫电子显微镜检查显示，基质金属蛋白酶-7在视网膜色素上皮细胞周围的基底膜沉积物和无定形物质中表达。这些结果支持基质金属蛋白酶-7在年龄相关性黄斑变性脉络膜新生血管形成过程中发挥作用。
