Green W R
Departments of Ophthalmology and Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Mol Vis. 1999 Nov 3;5:27.
Age-related macular degeneration is a diffuse condition involving the retinal pigment epithelium, the photoreceptor cell layer, and perhaps the choriocapillaris. The early morphologic change is the development of basal deposits of two distinct types. This phase is not ophthalmoscopically detectable but psychophysical testing may demonstrate reduced function. The process becomes detectable with the occurrence of secondary changes in the pigment epithelium, soft drusen formation, and choroidal neovascularization. A reparative response results in disciform scars. The various morphologic forms of age-related macular degeneration are interrelated.
年龄相关性黄斑变性是一种累及视网膜色素上皮、光感受器细胞层以及可能还有脉络膜毛细血管的弥漫性疾病。早期形态学改变是两种不同类型的基底沉积物的形成。此阶段在检眼镜下无法检测到，但心理物理学测试可能显示功能减退。随着色素上皮出现继发性改变、软性玻璃膜疣形成和脉络膜新生血管形成，该过程变得可检测到。修复反应会导致盘状瘢痕形成。年龄相关性黄斑变性的各种形态学形式相互关联。
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