丛集性头痛患者血浆中内皮素-1的水平
Endothelin-1 plasma levels in cluster headache.
作者信息
Franceschini R, Tenconi G L, Leandri M, Zoppoli F, Gonella A, Staltari S, Barreca T
机构信息
Division of Internal Medicine II, Department of Internal Medicine, University of Genoa, Italy.
出版信息
Headache. 2002 Feb;42(2):120-4. doi: 10.1046/j.1526-4610.2002.02027.x.
BACKGROUND AND OBJECTIVE
A role for endothelin-1, a potent vasoconstrictor peptide, in some cerebrovascular diseases has been proposed. To obtain preliminary data about peripheral concentrations of endothelin-1 in acute cluster headache, we measured the plasma endothelin-1 secretory pattern in 10 men with cluster during and independent of a headache attack.
METHODS
We collected blood samples for plasma endothelin-1 determinations at 0, 15, 30, 45, 60, 90, and 120 minutes during a cluster attack and closely monitored blood pressures. We repeated the same sampling during an asymptomatic period.
RESULTS
The mean values of plasma endothelin-1 (before a cluster headache, 3.3 +/- 0.3 pg/mL) significantly increased (F = 2.578, P < .05) during an attack, reaching their peak at 30 minutes (5.0 +/- 0.5 pg/mL, P < .05). We found no significant variations in mean arterial pressure.
CONCLUSION
Endothelin-1 may play a role in the pathophysiology of cluster attacks. The increase in plasma observed during cluster attacks may be linked to alterations in systemic hemodynamics and vascular tone.
背景与目的
内皮素 - 1作为一种强效血管收缩肽，在某些脑血管疾病中的作用已被提出。为获取关于急性丛集性头痛患者外周血中内皮素 - 1浓度的初步数据，我们测量了10名丛集性头痛男性患者在头痛发作期间及发作间期血浆内皮素 - 1的分泌模式。
方法
在丛集性头痛发作期间，于0、15、30、45、60、90和120分钟采集血样以测定血浆内皮素 - 1，并密切监测血压。在无症状期重复相同的采样。
结果
血浆内皮素 - 1的平均值（丛集性头痛发作前为3.3±0.3 pg/mL）在发作期间显著升高（F = 2.578，P < 0.05），在30分钟时达到峰值（5.0±0.5 pg/mL，P < 0.05）。我们发现平均动脉压无显著变化。
结论
内皮素 - 1可能在丛集性头痛发作的病理生理学中起作用。丛集性头痛发作期间观察到的血浆内皮素 - 1升高可能与全身血流动力学和血管张力的改变有关。
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