丛集性头痛发作期间血浆精氨酸加压素浓度升高。
Raised plasma arginine vasopressin concentrations during cluster headache attacks.
作者信息
Franceschini R, Leandri M, Cataldi A, Bruno E, Corsini G, Rolandi E, Barreca T
机构信息
Department of Internal Medicine, University of Genoa, Italy.
出版信息
J Neurol Neurosurg Psychiatry. 1995 Oct;59(4):381-3. doi: 10.1136/jnnp.59.4.381.
To obtain data about peripheral concentrations of arginine vasopressin in head pain syndromes, the plasma arginine vasopressin secretory pattern in 12 adult male patients with cluster headache was evaluated. Blood samples for plasma arginine vasopressin and osmolality determinations were collected before, and at 15, 30, 45, 60, 90, and 120 minutes during a cluster attack. Blood pressure was also monitored. The same sampling was repeated during an asymptomatic period. During cluster attacks, the mean values of plasma arginine vasopressin before an attack (2.3 (0.1) ng/l) significantly increased, reaching their peak at 45 minutes (4.8 (0.5) ng/l; P < 0.01 v baseline). No significant variations were found in mean arterial pressure and plasma osmolality. These data suggested involvement of neurotransmitter mechanisms regulating arginine vasopressin secretion and a possible role of arginine vasopressin in vasomotor phenomena accompanying cluster attacks.
为获取有关头痛综合征中精氨酸加压素外周浓度的数据，对12例丛集性头痛成年男性患者的血浆精氨酸加压素分泌模式进行了评估。在丛集性发作前、发作期间的15、30、45、60、90和120分钟采集血样，用于测定血浆精氨酸加压素和渗透压。同时监测血压。在无症状期重复相同的采样。在丛集性发作期间，发作前血浆精氨酸加压素的平均值（2.3（0.1）ng/l）显著升高，在45分钟时达到峰值（4.8（0.5）ng/l；与基线相比P<0.01）。平均动脉压和血浆渗透压未发现显著变化。这些数据表明调节精氨酸加压素分泌的神经递质机制参与其中，且精氨酸加压素在丛集性发作伴随的血管运动现象中可能发挥作用。
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