• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Expression of insulin-like growth factor (IGF), IGF receptor, and IGF-binding protein messenger ribonucleic acids in luteinized granulosa cells from different size follicles after controlled ovarian hyperstimulation.控制性卵巢过度刺激后不同大小卵泡来源的黄素化颗粒细胞中胰岛素样生长因子（IGF）、IGF受体及IGF结合蛋白信使核糖核酸的表达
J Assist Reprod Genet. 2002 Mar;19(3):121-6. doi: 10.1023/a:1014732704218.
2
Co-expression of messenger ribonucleic acids encoding IGF-I, IGF-II, type I and II IGF receptors and IGF-binding proteins (IGFBP-1 to -6) during follicular development in the ovary of seasonally anoestrous ewes.季节性乏情母羊卵巢卵泡发育过程中编码胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子-II（IGF-II）、I型和II型IGF受体以及IGF结合蛋白（IGFBP-1至-6）的信使核糖核酸的共表达。
Anim Reprod Sci. 2004 Aug;84(1-2):93-105. doi: 10.1016/j.anireprosci.2003.10.012.
3
Changes in mRNA expression of insulin-like growth factors and insulin-like growth factor-binding proteins in ovarian granulosa cells after cotreatment with growth hormone in low responders.低反应者在生长激素联合治疗后卵巢颗粒细胞中胰岛素样生长因子及其结合蛋白的mRNA表达变化
Chang Gung Med J. 2000 Nov;23(11):662-71.
4
Expression levels of mRNA for insulin-like growth factors 1 and 2, IGF receptors and IGF binding proteins in in vivo and in vitro grown bovine follicles.体内和体外生长的牛卵泡中胰岛素样生长因子1和2、IGF受体及IGF结合蛋白的mRNA表达水平
Zygote. 2014 Nov;22(4):521-32. doi: 10.1017/S0967199413000166. Epub 2013 May 9.
5
Effect of insulin-like growth factors (IGF), FSH, and leptin on IGF-binding-protein mRNA expression in bovine granulosa and theca cells: quantitative detection by real-time PCR.胰岛素样生长因子（IGF）、促卵泡激素（FSH）和瘦素对牛颗粒细胞和卵泡膜细胞中IGF结合蛋白mRNA表达的影响：实时PCR定量检测
Peptides. 2004 Dec;25(12):2195-203. doi: 10.1016/j.peptides.2004.07.008.
6
Effect of follicle size on in vitro production of steroids and insulin-like growth factor (IGF)-I, IGF-II, and the IGF-binding proteins by equine ovarian granulosa cells.卵泡大小对马卵巢颗粒细胞体外产生类固醇、胰岛素样生长因子（IGF）-I、IGF-II和IGF结合蛋白的影响。
Biol Reprod. 2002 Jun;66(6):1640-8. doi: 10.1095/biolreprod66.6.1640.
7
Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle.排卵前母牛优势卵泡和从属卵泡颗粒细胞中妊娠相关血浆蛋白-A和胰岛素样生长因子结合蛋白的mRNA
Domest Anim Endocrinol. 2005 Jan;28(1):46-63. doi: 10.1016/j.domaniend.2004.06.002.
8
Expression of mouse ovarian insulin growth factor system components during follicular development and atresia.小鼠卵巢胰岛素生长因子系统成分在卵泡发育和闭锁过程中的表达。
Endocrinology. 1998 Dec;139(12):5205-14. doi: 10.1210/endo.139.12.6367.
9
Insulin-like growth factor binding proteins in granulosa and thecal cells from bovine ovarian follicles at different stages of development.不同发育阶段牛卵泡颗粒细胞和膜细胞中的胰岛素样生长因子结合蛋白
J Anim Sci. 2003 Nov;81(11):2826-39. doi: 10.2527/2003.81112826x.
10
Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries.编码胰岛素样生长因子（IGF-I和IGF-II）、IGF及胰岛素受体以及IGF结合蛋白-1至6的基因表达及其基因产物在正常和多囊卵巢综合征卵巢中的定位。
J Clin Endocrinol Metab. 1994 Jun;78(6):1488-96. doi: 10.1210/jcem.78.6.7515389.

引用本文的文献

1
Differential gene expression in human granulosa cells from recombinant FSH versus human menopausal gonadotropin ovarian stimulation protocols.重组卵泡刺激素与人类绝经期促性腺激素卵巢刺激方案中人类颗粒细胞的差异基因表达。
Reprod Biol Endocrinol. 2010 Mar 12;8:25. doi: 10.1186/1477-7827-8-25.
2
Expression of the insulin-like growth factor and insulin systems in the luteinizing macaque ovarian follicle.胰岛素样生长因子和胰岛素系统在猕猴卵巢滤泡中的表达。
Fertil Steril. 2010 Mar 15;93(5):1421-9. doi: 10.1016/j.fertnstert.2008.12.096. Epub 2009 Feb 24.

本文引用的文献

1
The expression of DAZL1 in the ovary of the human female fetus.
Fertil Steril. 2000 Mar;73(3):627-30. doi: 10.1016/s0015-0282(99)00544-0.
2
Follicular and luteal expression of insulin-like growth factors I and II and the type 1 IGF receptor in the bovine ovary.牛卵巢中胰岛素样生长因子I和II以及1型胰岛素样生长因子受体的卵泡期和黄体期表达
J Reprod Fertil. 1999 May;116(1):157-65. doi: 10.1530/jrf.0.1160157.
3
Insulin-like growth factor-II mediates the steroidogenic and growth promoting actions of follicle stimulating hormone on human ovarian pre-antral follicles cultured in vitro.
J Clin Endocrinol Metab. 1999 Apr;84(4):1479-82. doi: 10.1210/jcem.84.4.5727.
4
Involvement of growth factors in the pathophysiology of polycystic ovary syndrome.生长因子在多囊卵巢综合征病理生理学中的作用
Gynecol Endocrinol. 1998 Dec;12(6):391-7. doi: 10.3109/09513599809012841.
5
Expression of mouse ovarian insulin growth factor system components during follicular development and atresia.小鼠卵巢胰岛素生长因子系统成分在卵泡发育和闭锁过程中的表达。
Endocrinology. 1998 Dec;139(12):5205-14. doi: 10.1210/endo.139.12.6367.
6
Follicle-stimulating hormone and insulin-like growth factor-I attenuate apoptosis in cultured porcine granulosa cells.
Biol Reprod. 1998 Feb;58(2):390-6. doi: 10.1095/biolreprod58.2.390.
7
The mouse intraovarian insulin-like growth factor I system: departures from the rat paradigm.小鼠卵巢内胰岛素样生长因子I系统：与大鼠模式的差异
Endocrinology. 1997 Sep;138(9):3881-90. doi: 10.1210/endo.138.9.5363.
8
Modulation of the insulin-like growth factor-binding proteins by follicle size in the human ovary.人类卵巢中卵泡大小对胰岛素样生长因子结合蛋白的调节作用。
J Endocrinol. 1997 Jul;154(1):35-43. doi: 10.1677/joe.0.1540035.
9
Insulin-like growth factor (IGF)-binding protein production by primary cultures of ovine granulosa and theca cells. The effects of IGF-I, gonadotropin, and follicle size.绵羊颗粒细胞和卵泡膜细胞原代培养物中胰岛素样生长因子（IGF）结合蛋白的产生。IGF-I、促性腺激素和卵泡大小的影响。
Biol Reprod. 1996 Nov;55(5):1163-71. doi: 10.1095/biolreprod55.5.1163.
10
Expression of insulin-like growth factor (IGF), IGF-binding protein, and IGF receptor messenger ribonucleic acids in normal and polycystic ovaries.胰岛素样生长因子（IGF）、IGF结合蛋白以及IGF受体信使核糖核酸在正常卵巢和多囊卵巢中的表达
J Clin Endocrinol Metab. 1996 Mar;81(3):1003-8. doi: 10.1210/jcem.81.3.8772565.

控制性卵巢过度刺激后不同大小卵泡来源的黄素化颗粒细胞中胰岛素样生长因子（IGF）、IGF受体及IGF结合蛋白信使核糖核酸的表达

Expression of insulin-like growth factor (IGF), IGF receptor, and IGF-binding protein messenger ribonucleic acids in luteinized granulosa cells from different size follicles after controlled ovarian hyperstimulation.

作者信息

Chang Shiuh Y, Tsai Meng-Yin, Huang Fu-Jen, Kung Fu-Tsai

机构信息

Medical School, Chang-Gung University, Taoyuan, Taiwan.

出版信息

J Assist Reprod Genet. 2002 Mar;19(3):121-6. doi: 10.1023/a:1014732704218.

DOI:10.1023/a:1014732704218
PMID:12005306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3468256/
Abstract

PURPOSE

This study was conducted to determine the gene expression of insulin-like growth factors (IGFs), their receptors, and binding proteins (IGFBPs) in human luteinized granulosa cells collected during ovum retrieval.

METHODS

cDNA probes were used to analyze the gene expression of IGF-I, IGF-II, IGF type 1 receptor (IGFR-1), IGF type 2 receptor (IGFR-2), and IGFBP-1 to -6 in luteinized granulosa cells.

RESULTS

The levels of IGFBP-5 transcripts of the luteinized granulosa cells increased with increasing follicular fluid (FF) volume when follicles were grouped into 3 volume catagories of < or = 1.5 mL: > 1.5 mL but < or = 4.5 mL; and > 4.5 mL (0.28 +/- 0.64 vs. 0.41 +/- 0.76 vs. 0.46 +/- 0.92, p = 0.037).

CONCLUSIONS

The increased levels of IGFBP-5 transcripts in luteinized granulosa cells found with increased follicular fluid volume after COH may favor a shift toward diminished action of IGFs in larger follicles immediately prior to ovulation.

摘要

目的

本研究旨在确定在取卵过程中收集的人黄素化颗粒细胞中胰岛素样生长因子（IGFs）、其受体及结合蛋白（IGFBPs）的基因表达情况。

方法

使用cDNA探针分析黄素化颗粒细胞中IGF-I、IGF-II、1型IGF受体（IGFR-1）、2型IGF受体（IGFR-2）以及IGFBP-1至-6的基因表达。

结果

当卵泡被分为<或=1.5 mL、>1.5 mL但<或=4.5 mL、>4.5 mL这3种体积类别时，黄素化颗粒细胞中IGFBP-5转录本水平随卵泡液（FF）体积增加而升高（0.28±0.64对0.41±0.76对0.46±0.92，p = 0.037）。

结论

在控制性卵巢刺激（COH）后，随着卵泡液体积增加，黄素化颗粒细胞中IGFBP-5转录本水平升高，这可能有利于在排卵前较大卵泡中向IGFs作用减弱的方向转变。