Price Stephen R, De Marco Garcia Natalia V, Ranscht Barbara, Jessell Thomas M
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, New York, NY 10032, USA.
Cell. 2002 Apr 19;109(2):205-16. doi: 10.1016/s0092-8674(02)00695-5.
During spinal cord development, motor neurons with common targets and afferent inputs cluster into discrete nuclei, termed motor pools. Motor pools can be delineated by transcription factor expression, but cell surface proteins that distinguish motor pools in a systematic manner have not been identified. We show that the developmentally regulated expression of type II cadherins defines specific motor pools. Expression of one type II cadherin, MN-cadherin, regulates the segregation of motor pools that are normally distinguished by expression of this protein. Type II cadherins are also expressed by proprioceptive sensory neurons, raising the possibility that cadherins regulate additional steps in the development of sensory-motor circuits.
在脊髓发育过程中，具有共同靶标和传入输入的运动神经元聚集形成离散的核，称为运动神经元池。运动神经元池可通过转录因子表达来划定，但尚未鉴定出以系统方式区分运动神经元池的细胞表面蛋白。我们发现II型钙黏蛋白的发育调控表达定义了特定的运动神经元池。一种II型钙黏蛋白MN-钙黏蛋白的表达调节通常由该蛋白表达所区分的运动神经元池的分离。本体感觉神经元也表达II型钙黏蛋白，这增加了钙黏蛋白调节感觉运动回路发育中其他步骤的可能性。
