白花鸡屎藤乙醇提取物对大鼠的抗糖尿病活性。
Anti-diabetic activity of alcoholic extract of Aerva lanata (L.) Juss. ex Schultes in rats.
作者信息
Vetrichelvan T, Jegadeesan M
机构信息
Adhiparasakthi College of Pharmacy, Melmaruvathur 603 319, Tamil Nadu, India.
出版信息
J Ethnopharmacol. 2002 May;80(2-3):103-7. doi: 10.1016/s0378-8741(01)00412-3.
Aerva lanata (L.) Juss. ex Schultes commonly known as 'Sunny khur' is widely used in Indian folk medicine for the treatment of Diabetes mellitus. This study was undertaken to evaluate the effect of an alcoholic extract of A. lanata (AAL) on blood glucose and other biochemical parameters in alloxan-induced diabetic rats. AAL was found to reduce the increase of blood sugar in alloxan-induced diabetic rats (42% at 375 mg/kg and 48% at 500 mg/kg body weight). Chronic administration of AAL significantly (P<0.001) reduced the blood sugar of alloxan induced diabetic rats for 2 weeks. Also the extract prevented a decrease in body weight and reduced the increased lipid peroxides in alloxan induced diabetic rats. These results suggest that the AAL posseses anti-diabetic activity and is able to ameliorate biochemical damages in alloxan induced diabetic rats.
白花苋（Aerva lanata (L.) Juss. ex Schultes），俗称“阳光胡尔”，在印度民间医学中被广泛用于治疗糖尿病。本研究旨在评估白花苋乙醇提取物（AAL）对四氧嘧啶诱导的糖尿病大鼠血糖及其他生化参数的影响。结果发现，AAL可降低四氧嘧啶诱导的糖尿病大鼠的血糖升高（体重375 mg/kg时降低42%，500 mg/kg时降低48%）。连续两周对四氧嘧啶诱导的糖尿病大鼠长期给予AAL可显著降低其血糖（P<0.001）。此外，该提取物可防止四氧嘧啶诱导的糖尿病大鼠体重下降，并降低其脂质过氧化物的增加。这些结果表明，AAL具有抗糖尿病活性，能够改善四氧嘧啶诱导的糖尿病大鼠的生化损伤。
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