青葙子种子乙醇提取物对大鼠的抗糖尿病活性。

Anti-diabetic activity of alcoholic extract of Celosia argentea Linn. seeds in rats.

作者信息

Vetrichelvan Thangarasu, Jegadeesan Maniappan, Devi Bangaru Adigalar Uma

机构信息

Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu, India.

出版信息

Biol Pharm Bull. 2002 Apr;25(4):526-8. doi: 10.1248/bpb.25.526.

DOI:10.1248/bpb.25.526

PMID:11995938

Abstract

Celosia argentea Linn. commonly known as "Cocks Comb" and its seeds are widely used in Indian folk medicine for the treatment of diabetes mellitus. This study was undertaken to evaluate the effect of an alcoholic extract of Celosia argentea seeds (ACAS) on blood glucose and body weight in alloxan-induced diabetic rats. ACAS was found to reduce the increase of blood glucose in alloxan-induced diabetic rats (27.8% at 250 mg/kg and 38.8% at 500 mg/kg body weight). Chronic administration of ACAS significantly (p<0.01) reduced the blood glucose in alloxan-induced diabetic rats for two weeks. Also the extract prevented a decrease in body weight in alloxan-induced diabetic rats. These results suggest that the ACAS possesses anti-diabetic activity in alloxan-induced diabetic rats.

摘要

鸡冠花，通常被称为“鸡冠”，其种子在印度民间医学中被广泛用于治疗糖尿病。本研究旨在评估鸡冠花种子乙醇提取物（ACAS）对四氧嘧啶诱导的糖尿病大鼠血糖和体重的影响。研究发现，ACAS可降低四氧嘧啶诱导的糖尿病大鼠的血糖升高（体重250mg/kg时降低27.8%，500mg/kg时降低38.8%）。连续两周对四氧嘧啶诱导的糖尿病大鼠长期给予ACAS可显著（p<0.01）降低其血糖。此外，该提取物可防止四氧嘧啶诱导的糖尿病大鼠体重下降。这些结果表明，ACAS对四氧嘧啶诱导的糖尿病大鼠具有抗糖尿病活性。