Sadler Ian J, Jacobsen Paul B, Booth-Jones Margaret, Belanger Heather, Weitzner Michael A, Fields Karen K
Psychosocial and Palliative Care Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
J Pain Symptom Manage. 2002 May;23(5):406-16. doi: 10.1016/s0885-3924(02)00388-3.
The objectives of this study were to evaluate the reliability, validity, and utility of a newly developed clinical syndrome approach to assessing cancer-related fatigue. Fifty-one patients who underwent blood or marrow transplantation an average of 6.9 months previously were administered a standardized interview designed to identify the presence of a clinical syndrome of cancer-related fatigue. Patients also completed self-report measures of fatigue, depression, and health-related quality of life. Comparisons among independent raters demonstrated high rates of reliability for the presence or absence of a cancer-related fatigue syndrome and its symptoms. Twenty-one percent of patients (n = 11) were found to meet criteria for diagnosis of a cancer-related fatigue syndrome. Compared to patients not meeting the diagnostic criteria, patients meeting the criteria reported fatigue that was greater (P < or = 0.05) in its severity, frequency, pervasiveness, and interference with quality of life. Patients who met criteria also demonstrated poorer role functioning, less vitality, and more depressive symptomatology (P < or = 0.05). These findings provide preliminary evidence of the reliability and validity of the methods used to assess the proposed clinical syndrome and suggest their utility in identifying patients experiencing clinically significant cancer-related fatigue.
本研究的目的是评估一种新开发的用于评估癌症相关疲劳的临床综合征方法的可靠性、有效性和实用性。对平均在6.9个月前接受血液或骨髓移植的51名患者进行了标准化访谈，以确定是否存在癌症相关疲劳的临床综合征。患者还完成了关于疲劳、抑郁和健康相关生活质量的自我报告测量。独立评估者之间的比较表明，癌症相关疲劳综合征及其症状的存在与否具有很高的可靠性。发现21%的患者（n = 11）符合癌症相关疲劳综合征的诊断标准。与未符合诊断标准的患者相比，符合标准的患者报告的疲劳在严重程度、频率、普遍性以及对生活质量的干扰方面更严重（P≤0.05）。符合标准的患者在角色功能方面也表现较差，活力较低，抑郁症状较多（P≤0.05）。这些发现为用于评估所提出的临床综合征的方法的可靠性和有效性提供了初步证据，并表明它们在识别经历临床上显著的癌症相关疲劳的患者方面的实用性。
