Murphy Helen, Alexander Susanna, Stone Patrick
Division of Mental Health, St. George's University of London, London, SW17 0RE, UK.
Palliat Med. 2006 Jun;20(4):413-8. doi: 10.1191/0269216306pm1145oa.
The primary aim of this study was to explore the feasibility of applying diagnostic criteria for cancer-related fatigue syndrome (CRFS) in patients with advanced cancer. A secondary aim was to assess the use of screening instruments for fatigue and depression in this population. Patients with advanced cancer (n=16) were interviewed using the Diagnostic Interview for CRFS and a semi-structured psychiatric interview. Subjects also completed the Bi-dimensional Fatigue Scale (BFS) and the Edinburgh Postnatal Depression Scale (EPDS) as screening instruments. The prevalence of psychiatric disorders was 50% (8/16). The EPDS was found to have a sensitivity of 67% and a specificity of 100% for detecting depression. The prevalence of clinically significant fatigue symptoms was 62.5% (10/16). The BFS was found to have a sensitivity of 70% and a specificity of 64% for detecting clinically significant fatigue. The prevalence of CRFS was 12.5% (2/16).
本研究的主要目的是探讨在晚期癌症患者中应用癌症相关疲劳综合征（CRFS）诊断标准的可行性。次要目的是评估该人群中疲劳和抑郁筛查工具的使用情况。使用CRFS诊断访谈和半结构化精神科访谈对16例晚期癌症患者进行了访谈。受试者还完成了二维疲劳量表（BFS）和爱丁堡产后抑郁量表（EPDS）作为筛查工具。精神障碍的患病率为50%（8/16）。发现EPDS检测抑郁症的敏感性为67%，特异性为100%。具有临床意义的疲劳症状的患病率为62.5%（10/16）。发现BFS检测具有临床意义的疲劳的敏感性为70%，特异性为64%。CRFS的患病率为12.5%（2/16）。
