重力对淋巴细胞增殖的影响。

Effect of gravity on lymphocyte proliferation.

作者信息

Cogoli A, Valluchi-Morf M, Bohringer H R, Vanni M R, Muller M

机构信息

Laboratorium fur Biochemie, Institut fur Zellbiologie, ETH-Zentrum, Zurich, Switzerland.

出版信息

Life Sci Space Res. 1979;17:219-24. doi: 10.1016/b978-0-08-023416-8.50032-5.

DOI:10.1016/b978-0-08-023416-8.50032-5

PMID:12008709

Abstract

Reports on postflight examination of lymphocytes from crew members of soviet and american spaceships show a depression of reactivity towards mitogens in vitro. The purpose of this communication is to present experimental evidence that gravity can interfere with lymphocyte activation. Lymphocytes were incubated in the presence of concanavalin A in a centrifuge at 2 and 4 g for four days. This environment causes a significant acceleration of the response to the mitogen. In addition, remarkable differences in the ultrastructure of cells grown at 1 g and 4 g are observed by electron microscopy. This investigation is related to the experiment "Effect of weightlessness on lymphocyte proliferation" experiment which will be performed during the first Spacelab mission.

摘要

关于苏联和美国宇宙飞船船员淋巴细胞飞行后检查的报告显示，淋巴细胞在体外对有丝分裂原的反应性降低。本通讯的目的是提供实验证据，证明重力可干扰淋巴细胞的激活。淋巴细胞在伴刀豆球蛋白A存在的情况下，于离心机中在2g和4g条件下培养四天。这种环境会导致对有丝分裂原反应的显著加速。此外，通过电子显微镜观察到在1g和4g条件下生长的细胞超微结构存在显著差异。本研究与将在首次太空实验室任务期间进行的“失重对淋巴细胞增殖的影响”实验相关。