Mulaisho C
Med J Zambia. 1979 Aug-Sep;13(4):64-7.
Serum total thyroxine (T4) was measured in clinically euthyroid and clinically hyperthyroid subjects, using the method of competitive protein binding. In 26 euthyroid subjects the mean +/- 1SD was 7.7 +/- 1.8 micrograms/dl and in 17 clinically hyperthyroid subjects, the mean +/- 1SD was 18.1 +/- 3.1 micrograms/dl. This difference is statistically significant. Serum % 125(1) -- T3 binding was measured using the principle of competition for 125(1) -- T3 between the unknown serum and the resin in the assay kit. In 18 clinically euthyroid subjects, the mean +/- 1SD was 112.6 +/- 4.4 % while in 14 clinically hyperthyroid subjects the % 125(1) -- T3 binding had a mean +/- 1SD of 71.4 +/- 11%. The difference is statistically significant. Serum total triiodothyronine was measured by radioimmunoassay. In 31 clinically euthyroid subjects the mean +/- 1SD was 146 +/- 19.8 ng/dl while in 19 clinically hyperthyroid sugjects the mean +/- 1SD was 390 +/- 111 ng/dl. This difference is statistically significant. There was a negative correlation which was not statistically significant between the serum T4 and % T3 binding. The measurements of these thyroid function indices were precise.
采用竞争性蛋白结合法对临床甲状腺功能正常和临床甲状腺功能亢进的受试者测定血清总甲状腺素（T4）。26名甲状腺功能正常的受试者，其均值±1标准差为7.7±1.8微克/分升；17名临床甲状腺功能亢进的受试者，其均值±1标准差为18.1±3.1微克/分升。这种差异具有统计学意义。采用试剂盒中未知血清与树脂竞争125I-T3的原理测定血清125I-T3结合率。18名临床甲状腺功能正常的受试者，其均值±1标准差为112.6±4.4%；14名临床甲状腺功能亢进的受试者，125I-T3结合率的均值±1标准差为71.4±11%。这种差异具有统计学意义。采用放射免疫分析法测定血清总三碘甲状腺原氨酸。31名临床甲状腺功能正常的受试者，其均值±1标准差为146±19.8纳克/分升；19名临床甲状腺功能亢进的受试者，其均值±1标准差为390±111纳克/分升。这种差异具有统计学意义。血清T4与T3结合率之间存在负相关，但无统计学意义。这些甲状腺功能指标的测量是精确的。
