Butera Peter C, Doerflinger Alicia L, Roberto Francesca
Department of Psychology, Niagara University, Niagara, NY 14109-2208, USA.
Brain Behav Immun. 2002 Jun;16(3):275-81. doi: 10.1006/brbi.2001.0621.
Proinflammatory cytokines elicit behavioral and physiological responses that include decreased food intake, fever, and a general disinterest in usual activities. Ovarian hormones modulate immune system activity and responsiveness to cytokines in female mammals, suggesting that sex differences in immune function may be influenced by gonadal steroids. In this experiment, female adult rats were ovariectomized and given two daily subcutaneous injections of 5.0 or 20.0 microg of estradiol benzoate or the oil vehicle 3 weeks after surgery. Following 2 days of hormone treatment, animals received ip injections of interleukin-1beta (IL-1beta) or saline 1 h before light offset. Food and water intake was measured 2 h after light offset. The results indicate that a cyclic pattern of estradiol treatment enhances the anorectic effect of IL-1beta and suggest that responses to immune system activation are influenced by estradiol.
促炎细胞因子引发行为和生理反应，包括食物摄入量减少、发热以及对日常活动普遍缺乏兴趣。卵巢激素调节雌性哺乳动物的免疫系统活动和对细胞因子的反应，这表明免疫功能的性别差异可能受性腺类固醇影响。在本实验中，成年雌性大鼠在手术后3周进行卵巢切除，并每天皮下注射两次5.0或20.0微克的苯甲酸雌二醇或油剂载体。在激素治疗2天后，动物在光照结束前1小时腹腔注射白细胞介素-1β（IL-1β）或生理盐水。在光照结束后2小时测量食物和水的摄入量。结果表明，雌二醇治疗的周期性模式增强了IL-1β的厌食作用，并表明对免疫系统激活的反应受雌二醇影响。
