对一个具有α地中海贫血特征和镰状细胞特征的家族进行的血红蛋白合成研究。
Hemoglobin synthesis studies of a family with alpha-thalassemia trait and sickle cell trait.
作者信息
Shaeffer J R, DeSimone J, Kleve L J
出版信息
Biochem Genet. 1975 Dec;13(11-12):783-8. doi: 10.1007/BF00484410.
PMID:1200978
Abstract
The ratio of total globin alpha to beta chain synthesis was determined in reticulocytes isolated from the blood of the members of a black family, some of whom had sickle cell trait with low blood HbS concentrations (25-30%). The results support the hypothesis that sickle cell trait individuals with low HbS concentrations also carry a gene for alpha-thalassemia.
摘要
在一个黑人家庭的成员血液中分离出的网织红细胞中，测定了总珠蛋白α链与β链合成的比例。该家庭中一些成员具有镰状细胞性状，血液中HbS浓度较低（25%-30%）。结果支持了这样一种假说，即HbS浓度较低的镰状细胞性状个体也携带α地中海贫血基因。
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