Sanchez D, Zudaire J J, Fernandez J M, Lopez J, Arocena J, Sanz G, Gimenez M, Rosell D, Robles J E, Berian J M
Department of Urology, Facultad di Medicina, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain.
BJU Int. 2002 Jun;89(9):912-6. doi: 10.1046/j.1464-410x.2002.02779.x.
To compare the performance of 18F-fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) in the follow-up of nonseminomatous germ cell tumours (NSGCT) in the retroperitoneum.
FDG-PET was used 25 times in 15 patients diagnosed with NSGCT. At the time of diagnosis five patients each were in stage I, II and III. Five patients had pure embryonal carcinoma, two had yolk sac tumours, one choriocarcinoma and seven had mixed tumours.
Eleven patients either presented with retroperitoneal disease or this did not disappear after chemotherapy. The results of both examinations coincided in 18 cases and were contradictory in the other seven, the difference being statistically significant (P=0.042).
In these patients FDG-PET detected the retroperitoneal relapse of NSGCT, in advanced stages treated with surgery plus chemotherapy, earlier than did CT; it also detected the presence of mature teratoma in residual retroperitoneal masses more accurately than CT. More extensive trials are needed before making conclusions about FDG-PET imaging as a routine method for NSGCT.
比较18F-氟-2-脱氧葡萄糖正电子发射断层扫描（FDG-PET）与计算机断层扫描（CT）在腹膜后非精原细胞瘤性生殖细胞肿瘤（NSGCT）随访中的表现。
15例诊断为NSGCT的患者共进行了25次FDG-PET检查。诊断时，I期、II期和III期患者各5例。5例为单纯胚胎癌，2例为卵黄囊瘤，1例为绒毛膜癌，7例为混合性肿瘤。
11例患者存在腹膜后疾病或化疗后疾病未消失。两种检查结果在18例中一致，在另外7例中相互矛盾，差异具有统计学意义（P = 0.042）。
在这些接受手术加化疗的晚期患者中，FDG-PET比CT更早检测到NSGCT的腹膜后复发；在检测残留腹膜后肿块中成熟畸胎瘤的存在方面，FDG-PET也比CT更准确。在将FDG-PET成像作为NSGCT的常规方法得出结论之前，还需要进行更广泛的试验。
