Mollanji R, Bozanovic-Sosic R, Zakharov A, Makarian L, Johnston M G
Trauma Research Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
Am J Physiol Regul Integr Comp Physiol. 2002 Jun;282(6):R1593-9. doi: 10.1152/ajpregu.00695.2001.
Cerebrospinal fluid (CSF) drains through the cribriform plate (CP) in association with the olfactory nerves. From this location, CSF is absorbed into nasal mucosal lymphatics. Recent data suggest that this pathway plays an important role in global CSF transport in sheep. In this report, we tested the hypothesis that blocking CSF transport through this pathway would elevate resting intracranial pressure (ICP). ICP was measured continuously from the cisterna magna of sheep before and after CP obstruction in the same animal. To block CSF transport through the CP, an external ethmoidectomy was performed. The olfactory and adjacent mucosa were removed, and the bone surface was sealed with tissue glue. To restrict our analysis to the cranial CSF system, CSF transport into the spinal subarachnoid compartment was prevented with a ligature tightened around the thecal sac between C1 and C2. Sham surgical procedures had no significant effects, but in the experimental group CP obstruction elevated ICP significantly. Mean postobstruction steady-state pressures (18.0 +/- 3.8 cmH(2)O) were approximately double the preobstruction values (9.2 +/- 0.9 cmH(2)O). These data support the concept that the olfactory pathway represents a major site for CSF drainage.
脑脊液（CSF）与嗅神经一起通过筛板（CP）引流。脑脊液从这个位置被吸收到鼻黏膜淋巴管中。最近的数据表明，这条途径在绵羊脑脊液的整体运输中起着重要作用。在本报告中，我们检验了这样一个假设：阻断脑脊液通过这条途径的运输会升高静息颅内压（ICP）。在同一动物的CP阻塞前后，连续测量绵羊枕大池的ICP。为了阻断脑脊液通过CP的运输，进行了外部筛窦切除术。切除嗅黏膜和相邻黏膜，并用组织胶封闭骨表面。为了将我们的分析局限于颅脑脊液系统，在C1和C2之间用结扎线收紧硬脊膜囊，以防止脑脊液进入脊髓蛛网膜下腔。假手术没有显著影响，但在实验组中，CP阻塞显著升高了ICP。阻塞后平均稳态压力（18.0±3.8 cmH₂O）约为阻塞前值（9.2±0.9 cmH₂O）的两倍。这些数据支持了嗅通路是脑脊液引流主要部位的概念。
