Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.
Department of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Int J Mol Sci. 2023 Sep 5;24(18):13696. doi: 10.3390/ijms241813696.
Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.
六十多年来，激光技术经历了一场技术革命，成为生物医学，特别是神经科学、神经退行性疾病和脑肿瘤的主要工具之一。胶质母细胞瘤是最致命的脑癌形式，治疗选择非常有限，预后不良。在这项针对大鼠的研究中，我们证明了基于量子点的 1267nm 激光二极管的无光敏剂激光治疗（PS-free-LT）可以抑制胶质母细胞瘤（GBM）的生长。这种波长高度吸收氧气，能够将三重态氧转化为单重态。应用 1267nm 激光照射 4 周，总剂量为 12.7kJ/cm2，可有效抑制 GBM 生长，将生存率从 34%提高到 64%，这可能是通过 LT 激活的细胞凋亡、抑制肿瘤细胞增殖、降低颅内压以及刺激淋巴引流和清除功能实现的。无 PS-LT 是一种很有前途的突破性技术，可用于治疗婴儿的浅表 GBM 以及对 PS 高度敏感或过敏的成年患者。
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