Killestein J, Hoogervorst E L J, Reif M, Kalkers N F, Van Loenen A C, Staats P G M, Gorter R W, Uitdehaag B M J, Polman C H
Department of Neurology, VU Medical Center, Amsterdam, the Netherlands.
Neurology. 2002 May 14;58(9):1404-7. doi: 10.1212/wnl.58.9.1404.
The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.
作者对16名患有严重痉挛的多发性硬化症患者进行了一项随机、双盲、安慰剂对照、双交叉研究，以调查口服Δ⁹-四氢大麻酚（THC）和大麻植物提取物的安全性、耐受性和疗效。两种药物都是安全的，但植物提取物治疗的不良事件更为常见。与安慰剂相比，THC和植物提取物治疗均未减轻痉挛。THC和植物提取物治疗均使参与者的整体印象变差。
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