Brecher P, Kessler M, Chobanian A V
Atherosclerosis. 1975 Nov-Dec;22(3):485-9. doi: 10.1016/0021-9150(75)90027-1.
The activity of fatty acyl CoA synthetase and fatty acyl CoA:cholesterol acyltransferase was determined in microsomal fractions from normal and atherosclerotic rabbit aortic tissue. No change in fatty acyl CoA synthetase activity was observed as a result of cholesterol feeding in contrast to the several-fold increase in the activity of fatty acyl CoA:cholesterol acyltransferase seen in atherosclerotic tissue. Inhibition of both enzymes was observed when clofibrate, or the tetrahydronapthyl analog of this drug were added in vitro. The inhibitory effects were most pronounced on the fatty acyl CoA:cholesterol acyltransferase.
测定了正常和动脉粥样硬化兔主动脉组织微粒体部分中脂肪酰辅酶A合成酶以及脂肪酰辅酶A：胆固醇酰基转移酶的活性。与动脉粥样硬化组织中脂肪酰辅酶A：胆固醇酰基转移酶活性增加数倍形成对比的是，喂食胆固醇后未观察到脂肪酰辅酶A合成酶活性有变化。当在体外添加氯贝丁酯或该药物的四氢萘基类似物时，两种酶均受到抑制。抑制作用对脂肪酰辅酶A：胆固醇酰基转移酶最为明显。
