Hudson K, Day A J
Atherosclerosis. 1982 Oct;45(1):109-13. doi: 10.1016/0021-9150(82)90176-9.
Bezafibrate markedly reduced the activity of fatty acyl CoA:cholesterol acyltransferase (ACAT) in the microsomal fraction of aortas from cholesterol-fed rabbits, while clofibrate was a less potent inhibitor. The activity of lysosomal cholesterol ester hydrolase (LCEH) was not significantly affected by either agent, indicating that inhibition of ACAT rather than stimulation of LCEH is a mechanism whereby these agents may decrease the cholesterol ester content of atherosclerotic aorta.
苯扎贝特显著降低了喂食胆固醇的兔子主动脉微粒体部分中脂肪酰基辅酶A：胆固醇酰基转移酶（ACAT）的活性，而氯贝丁酯的抑制作用较弱。两种药物对溶酶体胆固醇酯水解酶（LCEH）的活性均无显著影响，这表明这些药物降低动脉粥样硬化主动脉中胆固醇酯含量的机制是抑制ACAT，而非刺激LCEH。
