Chomette G, Auriol M, Tereau Y
Ann Anat Pathol (Paris). 1979;24(3):203-14.
Immunofluorescent study of paraffin sections of 80 lesions of the buccal cavity, for the most part malignant or pre-malignant revealed marked plasmocytosis in premalignant or early malignant cases. This plasmocytosis, easily seen by the use of anti-immunoglobulin sera, is of polyclonal type, with marked preponderance of IgG secretors. In infiltrating carcinomas and in recurrences, the number of plasmocytes decreases and the percentage of IgG secretors falls markedly. By contrast, that of IgA immunocytes remains the same. The significance of these findings is considered and their practical value in the surveillance of cases of leukoplasia is stressed.
对80例口腔病变石蜡切片进行免疫荧光研究，这些病变大多为恶性或癌前病变，结果显示癌前或早期恶性病例中有明显的浆细胞增多。这种浆细胞增多通过使用抗免疫球蛋白血清很容易观察到，属于多克隆类型，以分泌IgG的细胞占明显优势。在浸润性癌和复发病例中，浆细胞数量减少，分泌IgG的细胞百分比显著下降。相比之下，分泌IgA的免疫细胞数量保持不变。文中对这些发现的意义进行了探讨，并强调了它们在白斑病例监测中的实际价值。
