霍奇金淋巴瘤患者血清IgE升高是多克隆起源的。
Increased serum IgE in Hodgkin's disease is of polyclonal origin.
作者信息
Landaas T O, Grimmer O, Heier H E, Godal T
出版信息
Acta Pathol Microbiol Scand C. 1979 Dec;87(6):377-80.
The light chain of serum IgE from 4 untreated patients with Hodgkin's disease with elevated IgE levels was studied by an immunoadsorbent technique. Serum IgE was found to contain both kappa and lambda light chains in all cases studied. In addition an association between serum levels of IgE and that of IgA, IgG, and IgM was demonstrated. These findings make it unlikely that increased serum IgE in Hodgkin's disease is of monoclonal origin and support the view that serum IgE in such patients reflects a general disturbance in the regulation of their humoral immune response.
采用免疫吸附技术研究了4例未经治疗、IgE水平升高的霍奇金病患者血清IgE的轻链。在所有研究病例中，血清IgE均同时含有κ和λ轻链。此外，还证实了血清IgE水平与IgA、IgG和IgM水平之间存在关联。这些发现表明，霍奇金病患者血清IgE升高不太可能源于单克隆，支持了这样一种观点，即此类患者的血清IgE反映了其体液免疫反应调节的普遍紊乱。
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