Bullough W S, Deol J U
Br J Dermatol. 1975 Oct;93(4):417-24. doi: 10.1111/j.1365-2133.1975.tb06515.x.
Evidence is presented that dermo--epidermal adhesion is low in mouse ear. Consequently the pressure caused by mitotic activity in the basal epidermal layer is readily relieved by cell extrusion distally and the number of basal cells per unit skin area remains low. The rule then is that the number of distal cells per unit skin area must be equally low, and the epidermis is therefore thin. Conversely, dermo--epidermal adhesion is high in mouse sole-of-foot epidermis, and the mitotic pressure leads through cell crowding to a columnar basal epithelium. Furthermore, in the footpad centre, where adhesion is evidently highest, the baseline folds. With basal cell crowding and baseline folding there are more basal cells, and therefore more distal cells, per unit skin area. The epidermis is thick. Epidermal cells are regarded as equipotential. The different epidermal characteristics of the different body regions are determined by the combined actions of the local mitotic rate and the local strength of the dermal grip.
有证据表明，小鼠耳部的真皮 - 表皮黏附力较低。因此，基底表皮层有丝分裂活动所产生的压力很容易通过细胞向远端挤出而得到缓解，单位皮肤面积的基底细胞数量保持较低水平。那么规律就是，单位皮肤面积的远端细胞数量也必然同样较低，所以表皮较薄。相反，小鼠足底表皮的真皮 - 表皮黏附力较高，有丝分裂压力通过细胞拥挤导致柱状基底上皮的形成。此外，在黏附力显然最高的足垫中心，基底褶皱。随着基底细胞拥挤和基底褶皱的出现，单位皮肤面积的基底细胞更多，因此远端细胞也更多。表皮较厚。表皮细胞被视为具有同等潜能。身体不同部位不同的表皮特征是由局部有丝分裂率和真皮抓握力的局部强度共同作用决定的。
