Mayrink Wilson, Santos Gilmara Cristina dos, Toledo Vicente de Paulo Coelho Peixoto de, Guimaraes Tânia Mara Pinto Dabés, Machado-Coelho George Luis Lins, Genaro Odair, da Costa Carlos Alberto
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG.
Rev Soc Bras Med Trop. 2002 Mar-Apr;35(2):125-32. doi: 10.1590/s0037-86822002000200001.
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin(R) and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
用来自五种利什曼原虫株的抗原提取物对C57BL/10小鼠进行免疫接种。Leishvacin(R)和PH8单价疫苗在免疫动物脾细胞培养上清液中产生的干扰素-γ水平最高。在用亚马逊利什曼原虫（利什曼原虫属）前鞭毛体攻击六个月后，每个单菌株免疫组均显示出保护性免疫的证据。免疫组之间未检测到差异。可以得出结论，由单一利什曼原虫株组成的疫苗可以为C57BL/10小鼠提供针对亚马逊利什曼原虫感染的保护。
