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用于治疗胃溃疡的传统药物中天然化合物的抗氧化特性。

Antioxidant properties of natural compounds used in popular medicine for gastric ulcers.

作者信息

Repetto M G, Llesuy S F

机构信息

Laboratorio de Estrés Oxidativo en Patologías Humanas, Cátedra de Química General e Inorgánica, Departamento de Química Analítica y Fisicoquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.

出版信息

Braz J Med Biol Res. 2002 May;35(5):523-34. doi: 10.1590/s0100-879x2002000500003.

Abstract

There is evidence concerning the participation of reactive oxygen species in the etiology and physiopathology of human diseases, such as neurodegenerative disorders, inflammation, viral infections, autoimmune pathologies, and digestive system disorders such as gastrointestinal inflammation and gastric ulcer. The role of these reactive oxygen species in several diseases and the potential antioxidant protective effect of natural compounds on affected tissues are topics of high current interest. To consider a natural compound or a drug as an antioxidant substance it is necessary to investigate its antioxidant properties in vitro and then to evaluate its antioxidant functions in biological systems. In this review article, we shall consider the role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol.

摘要

有证据表明活性氧参与人类疾病的病因和病理生理过程,如神经退行性疾病、炎症、病毒感染、自身免疫性疾病以及消化系统疾病,如胃肠道炎症和胃溃疡。这些活性氧在多种疾病中的作用以及天然化合物对受影响组织的潜在抗氧化保护作用是当前备受关注的话题。要将一种天然化合物或药物视为抗氧化物质,有必要在体外研究其抗氧化特性,然后评估其在生物系统中的抗氧化功能。在这篇综述文章中,我们将探讨源自常见植物的天然抗氧化剂在减轻或预防乙醇诱导的胃溃疡氧化应激中的作用。

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