Leslie J, Langler D, Serjeant G R, Serjeant B E, Desai P, Gordon Y B
Br J Haematol. 1975 Jun;30(2):159-66. doi: 10.1111/j.1365-2141.1975.tb00530.x.
Coagulation studies were carried out in 117 Jamaicans with homozygous sickle-cell disease in the steady state, and 40 local controls. The patients had significantly higher factor-VIII levels, higher platelet counts, lower factor-V and plasminogen levels, shorter thrombin times and higher serum fibrinogen degradation products (FDP) than the control group. The low factor-V and plasminogen levels, and high FDP levels, might be explained by activation of the coagulation system and continuous clot lysis even in the absence of painful crisis. The high factor-VIII levels and short thrombin times found in these patients could not be explained.
对117名处于稳定状态的纯合子镰状细胞病牙买加患者以及40名当地对照者进行了凝血研究。与对照组相比，患者的因子VIII水平显著更高、血小板计数更高、因子V和纤溶酶原水平更低、凝血酶时间更短且血清纤维蛋白原降解产物（FDP）更高。即使在没有疼痛危象的情况下，凝血系统的激活和持续的血栓溶解可能解释了低因子V和纤溶酶原水平以及高FDP水平。这些患者中发现的高因子VIII水平和短凝血酶时间无法得到解释。
