镰状细胞病中的血小板高活性：脾功能减退的后果。
Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism.
作者信息
Kenny M W, George A J, Stuart J
出版信息
J Clin Pathol. 1980 Jul;33(7):622-5. doi: 10.1136/jcp.33.7.622.
Abstract
Platelet function was measured on 29 occasions in 16 adult patients in the asymptomatic steady state of sickle-cell anaemia. There was a significant increase in platelet number and micro-aggregate formation, and a lower aggregation threshold with adenosine diphosphate, compared with 23 healthy controls. Similar changes were found, however, in 12 splenectomised patients without sickle-cell diseases. The platelet hyperactivity of the sickle-cell steady state therefore reflects an increased circulating population of young, metabolically active platelets resulting from previous autosplenectomy.
摘要
对16例处于镰状细胞贫血无症状稳定期的成年患者进行了29次血小板功能检测。与23名健康对照者相比，患者的血小板数量和微聚集体形成显著增加，对二磷酸腺苷的聚集阈值降低。然而，在12例无镰状细胞疾病的脾切除患者中也发现了类似变化。因此，镰状细胞稳定期的血小板功能亢进反映了由于先前的自体脾切除导致循环中年轻、代谢活跃的血小板数量增加。
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